diff --git a/pyproject.toml b/pyproject.toml
index 7cff60362a4b..d85c7f2af08b 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -94,7 +94,7 @@ dependencies = [
   "sentry-sdk[http2]>=2.59.0",
   "sentry-usage-accountant>=0.0.10",
   # remove once there are no unmarked transitive dependencies on setuptools
-  "setuptools>=70.0.0",
+  "setuptools>=78.1.1",
   "simplejson>=3.17.6",
   "slack-sdk>=3.40.1",
   "snuba-sdk>=3.0.43",
diff --git a/uv.lock b/uv.lock
index ded086d3c4bf..f4132c32285c 100644
--- a/uv.lock
+++ b/uv.lock
@@ -2355,7 +2355,7 @@ requires-dist = [
     { name = "sentry-scm", specifier = ">=0.14.0" },
     { name = "sentry-sdk", extras = ["http2"], specifier = ">=2.59.0" },
     { name = "sentry-usage-accountant", specifier = ">=0.0.10" },
-    { name = "setuptools", specifier = ">=70.0.0" },
+    { name = "setuptools", specifier = ">=78.1.1" },
     { name = "simplejson", specifier = ">=3.17.6" },
     { name = "slack-sdk", specifier = ">=3.40.1" },
     { name = "snuba-sdk", specifier = ">=3.0.43" },
@@ -2615,10 +2615,10 @@ wheels = [
 
 [[package]]
 name = "setuptools"
-version = "70.0.0"
+version = "78.1.1"
 source = { registry = "https://pypi.devinfra.sentry.io/simple" }
 wheels = [
-    { url = "https://pypi.devinfra.sentry.io/wheels/setuptools-70.0.0-py3-none-any.whl", hash = "sha256:54faa7f2e8d2d11bcd2c07bed282eef1046b5c080d1c32add737d7b5817b1ad4" },
+    { url = "https://pypi.devinfra.sentry.io/wheels/setuptools-78.1.1-py3-none-any.whl", hash = "sha256:c3a9c4211ff4c309edb8b8c4f1cbfa7ae324c4ba9f91ff254e3d305b9fd54561" },
 ]
 
 [[package]]