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-# .github
-Focus on Immuno-Oncology and Precision Oncology
+# 🧬 LiaoWJLab 
+
+> 🎯 Focus on Immuno-Oncology and Precision Oncology
+
+## 👋 欢迎 Welcome
+
+欢迎来到 LiaoWJLab！我们是一个专注于**免疫肿瘤学**和**精准肿瘤学**研究的团队，致力于通过生物信息学和机器学习方法开发创新的肿瘤免疫治疗预测工具。
+
+Welcome to LiaoWJLab! We are a research team focused on **Immuno-Oncology** and **Precision Oncology**, dedicated to developing innovative tumor immunotherapy prediction tools through bioinformatics and machine learning approaches.
+
+---
+
+## 🔬 研究方向 Research Areas
+
+- 🧫 **肿瘤微环境分析** Tumor Microenvironment Analysis
+- 💊 **免疫治疗响应预测** Immunotherapy Response Prediction  
+- 🧪 **单细胞测序分析** Single-Cell Sequencing Analysis
+- 🎯 **精准医疗** Precision Medicine
+- 🤖 **人工智能在肿瘤学中的应用** AI in Oncology
+
+---
+
+## 📚 公开项目 Public Projects
+
+### 🏆 TMEclassifier
+[![Stars](https://img.shields.io/github/stars/LiaoWJLab/TMEclassifier?style=social)](https://github.com/LiaoWJLab/TMEclassifier)
+[![Language](https://img.shields.io/badge/Language-R-blue)](https://github.com/LiaoWJLab/TMEclassifier)
+[![License](https://img.shields.io/badge/License-GPL--3.0-green)](https://github.com/LiaoWJLab/TMEclassifier)
+
+**肿瘤微环境分型分类器 | Tumor Microenvironment Classifier**
+
+基于集成机器学习模型的肿瘤微环境亚型分类器，专注于胃癌免疫治疗预测。
+
+A classifier for tumor microenvironment subtype based on ensemble machine learning models, focusing on gastric cancer immunotherapy prediction.
+
+🔗 [Repository](https://github.com/LiaoWJLab/TMEclassifier) | 📊 Topics: `gastric-cancer` `immunotherapy` `tumor-microenvironment`
+
+---
+
+### 🫁 LIRA
+[![Stars](https://img.shields.io/github/stars/LiaoWJLab/LIRA?style=social)](https://github.com/LiaoWJLab/LIRA)
+[![Language](https://img.shields.io/badge/Language-R-blue)](https://github.com/LiaoWJLab/LIRA)
+[![License](https://img.shields.io/badge/License-GPL--3.0-green)](https://github.com/LiaoWJLab/LIRA)
+
+**肺癌免疫治疗响应人工智能模型 | Lung Cancer Immunotherapy Response AI Model**
+
+专门为肺癌患者免疫治疗响应预测开发的人工智能模型，助力临床决策。
+
+An artificial intelligence model specifically developed for predicting immunotherapy response in lung cancer patients, supporting clinical decision-making.
+
+🔗 [Repository](https://github.com/LiaoWJLab/LIRA)
+
+---
+
+### 🎯 IKCscore
+[![Stars](https://img.shields.io/github/stars/LiaoWJLab/IKCscore?style=social)](https://github.com/LiaoWJLab/IKCscore)
+[![Language](https://img.shields.io/badge/Language-R-blue)](https://github.com/LiaoWJLab/IKCscore)
+[![License](https://img.shields.io/badge/License-GPL--3.0-green)](https://github.com/LiaoWJLab/IKCscore)
+
+**非小细胞肺癌免疫治疗预测评分 | NSCLC Immunotherapy Prediction Score**
+
+用于非小细胞肺癌免疫治疗预测的评分计算工具。
+
+Score calculation tool for immunotherapy prediction of non-small cell lung cancer.
+
+🔗 [Repository](https://github.com/LiaoWJLab/IKCscore)
+
+---
+
+### 🧬 scsig
+[![Stars](https://img.shields.io/github/stars/LiaoWJLab/scsig?style=social)](https://github.com/LiaoWJLab/scsig)
+[![Language](https://img.shields.io/badge/Language-R-blue)](https://github.com/LiaoWJLab/scsig)
+[![License](https://img.shields.io/badge/License-GPL--3.0-green)](https://github.com/LiaoWJLab/scsig)
+
+**单细胞差异特征识别工具 | Single-Cell Differential Signature Identification**
+
+用于识别单细胞水平差异特征的功能工具集。
+
+Functions to identify single cell differential signatures.
+
+🔗 [Repository](https://github.com/LiaoWJLab/scsig)
+
+---
+
+### 🧪 FBI
+[![Stars](https://img.shields.io/github/stars/LiaoWJLab/FBI?style=social)](https://github.com/LiaoWJLab/FBI)
+[![Language](https://img.shields.io/badge/Language-Shell-green)](https://github.com/LiaoWJLab/FBI)
+[![License](https://img.shields.io/badge/License-MIT-yellow)](https://github.com/LiaoWJLab/FBI)
+
+**融合负荷指数分析流程 | Fusion Burden Index Analysis Pipeline**
+
+用于基因融合负荷指数分析的生物信息学流程。
+
+Bioinformatics pipeline for Fusion Burden Index analysis.
+
+🔗 [Repository](https://github.com/LiaoWJLab/FBI)
+
+---
+
+### 💧 uaiscore
+[![Stars](https://img.shields.io/github/stars/LiaoWJLab/uaiscore?style=social)](https://github.com/LiaoWJLab/uaiscore)
+[![Language](https://img.shields.io/badge/Language-R-blue)](https://github.com/LiaoWJLab/uaiscore)
+[![License](https://img.shields.io/badge/License-GPL--3.0-green)](https://github.com/LiaoWJLab/uaiscore)
+
+**尿路上皮癌辅助免疫治疗分层工具 | Urothelial Carcinoma Adjuvant Immunotherapy Stratification**
+
+实现尿路上皮癌辅助免疫治疗的精准分层。
+
+UAIscore enables precise stratification of adjuvant immunotherapy in urothelial carcinoma.
+
+🔗 [Repository](https://github.com/LiaoWJLab/uaiscore)
+
+---
+
+## 🌟 核心特色 Key Features
+
+- 🎓 **学术导向** Academic-oriented research and development
+- 🔓 **开源共享** Open-source tools and resources
+- 📈 **临床应用** Clinical application-focused solutions
+- 🤝 **合作开放** Open for collaboration and contribution
+- 🌍 **国际视野** International perspective in oncology research
+
+---
+
+## 📫 联系我们 Contact Us
+
+如有合作意向或技术问题，欢迎通过以下方式联系我们：
+
+For collaboration or technical questions, feel free to reach out:
+
+- 📧 通过 GitHub Issues 联系各项目团队
+- 🐛 报告问题或建议改进
+- 🤝 欢迎贡献代码和想法
+
+---
+
+## 📜 License
+
+大多数项目采用 GPL-3.0 或 MIT 许可证。具体许可证信息请查看各项目仓库。
+
+Most projects are licensed under GPL-3.0 or MIT License. Please check individual repositories for specific license information.
+
+---
+
+<div align="center">
+
+**🧬 Advancing Cancer Treatment Through Data Science 🧬**
+
+*用数据科学推进癌症治疗*
+
+[![GitHub Organization](https://img.shields.io/badge/GitHub-LiaoWJLab-blue?style=flat&logo=github)](https://github.com/LiaoWJLab)
+
+</div>