diff --git a/requirements.txt b/requirements.txt
index dbd943b0..bdb23c36 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -15,6 +15,6 @@ transformers>=4.43.0,<4.53.0
 cellxgene-census>=1.15.0, <2.0.0
 gget>=0.28.4,<1.0.0
 pydantic>=2.6.3,<3.0.0
-rdkit>=2023.9.5,<2024.3.1
+rdkit>=2023.9.5,<2025.3.4
 tiledbsoma>=1.7.2,<2.0.0
 tiledb  # required for cellxgene_census.py