diff --git a/changelog/fix_false_positives_for_rails_presence_with_comparison_and_assignment_operators.md b/changelog/fix_false_positives_for_rails_presence_with_comparison_and_assignment_operators.md
new file mode 100644
index 0000000000..1830b15169
--- /dev/null
+++ b/changelog/fix_false_positives_for_rails_presence_with_comparison_and_assignment_operators.md
@@ -0,0 +1 @@
+* [#1557](https://github.com/rubocop/rubocop-rails/issues/1557): Fix false positives for `Rails/Presence` with comparison and assignment operators. ([@davidenglishmusic][])
diff --git a/lib/rubocop/cop/rails/presence.rb b/lib/rubocop/cop/rails/presence.rb
index e612eaf6ca..517f7c7a48 100644
--- a/lib/rubocop/cop/rails/presence.rb
+++ b/lib/rubocop/cop/rails/presence.rb
@@ -53,6 +53,16 @@ module Rails
       #
       #   # good
       #   a.presence&.foo
+      #
+      #   # good
+      #   a.present? ? a[1] : nil
+      #
+      #   # good
+      #   a[:key] = value if a.present?
+      #
+      #   # good
+      #   a.present? ? a > 1 : nil
+      #   a <= 0 if a.present?
       class Presence < Base
         include RangeHelp
         extend AutoCorrector
@@ -130,7 +140,7 @@ def ignore_other_node?(node)
         end
 
         def ignore_chain_node?(node)
-          node.method?('[]') || node.arithmetic_operation?
+          node.method?('[]') || node.method?('[]=') || node.arithmetic_operation? || node.comparison_method?
         end
 
         def message(node, replacement)
diff --git a/spec/rubocop/cop/rails/presence_spec.rb b/spec/rubocop/cop/rails/presence_spec.rb
index 433c8ca3b2..382978fb4d 100644
--- a/spec/rubocop/cop/rails/presence_spec.rb
+++ b/spec/rubocop/cop/rails/presence_spec.rb
@@ -295,12 +295,30 @@
       RUBY
     end
 
+    it 'does not register an offense when chained method is `[]=`' do
+      expect_no_offenses(<<~RUBY)
+        a[1] = 1 if a.present?
+      RUBY
+    end
+
     it 'does not register an offense when chained method is an arithmetic operation' do
       expect_no_offenses(<<~RUBY)
         a.present? ? a + 42 : nil
       RUBY
     end
 
+    it 'does not register an offense when using comparison operation in modifier if' do
+      expect_no_offenses(<<~RUBY)
+        a <= 0 if a.present?
+      RUBY
+    end
+
+    it 'does not register an offense when chained method is a comparison operation in ternary' do
+      expect_no_offenses(<<~RUBY)
+        a.present? ? a > 42 : nil
+      RUBY
+    end
+
     it 'does not register an offense when multiple methods are chained' do
       expect_no_offenses(<<~RUBY)
         a.present? ? a.foo.bar : nil