diff --git a/library/std/src/sys/fs/unix.rs b/library/std/src/sys/fs/unix.rs
index 1045a7b7e2f56..acd2c7f5dfbd1 100644
--- a/library/std/src/sys/fs/unix.rs
+++ b/library/std/src/sys/fs/unix.rs
@@ -1884,6 +1884,13 @@ pub fn set_perm(p: &CStr, perm: FilePermissions) -> io::Result<()> {
     cvt_r(|| unsafe { libc::chmod(p.as_ptr(), perm.mode) }).map(|_| ())
 }
 
+#[cfg(target_os = "vxworks")]
+pub fn set_perm_nofollow(_p: &CStr, _perm: FilePermissions) -> io::Result<()> {
+    // VxWorks has no `O_NOFOLLOW`, and its `fchmodat` rejects
+    // `AT_SYMLINK_NOFOLLOW` with `ENOTSUP`, so a no-follow chmod is unsupported.
+    Err(crate::io::ErrorKind::Unsupported.into())
+}
+
 #[cfg(target_os = "android")]
 pub fn set_perm_nofollow(_p: &CStr, _perm: FilePermissions) -> io::Result<()> {
     // Currently Android seems to be having inconsistent behavior with fchmodat
@@ -1896,7 +1903,7 @@ pub fn set_perm_nofollow(_p: &CStr, _perm: FilePermissions) -> io::Result<()> {
     Err(crate::io::ErrorKind::Unsupported.into())
 }
 
-#[cfg(not(target_os = "android"))]
+#[cfg(not(any(target_os = "android", target_os = "vxworks")))]
 pub fn set_perm_nofollow(p: &CStr, perm: FilePermissions) -> io::Result<()> {
     #[inline]
     /// Helper function for fallback open with `O_NOFOLLOW` + `fchmod` behavior